Polymeric Nanoparticles - the new face in Drug Delivery and Cancer Therapy

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Authors :

Meshak Dhanashekaran Cecileya Jasmine1 and Venugopal Vinod Prabhu2*

Author Address :

1Department of Biochemistry, KGF College of Dental Sciences and Hospital, KGF-563115, Karnataka, India.
2Department of Biotechnology, Karunya University, Coimbatore-641114, Tamil Nadu, India
* For correspondence email: vinodprabu2k@gmail.com

Abstract :

Nanotechnology has been widely focused throughout the world for their efficacy, specificity, tolerability and therapeutic index of the drugs. Nanoparticles (NPs) mediated targeting plays a significant role in inhibiting inflammation, angiogenesis and tumor progression. Especially polymeric NPs have greater deal that provides numerous properties such as simple to synthesize, inexpensive, biocompatible, biodegradable, non-toxic, non-immunogenic and water soluble for an effective drug delivery and drug targeting. This review discusses recent advancement in the development of drug delivery and drug targeting using polymeric NPs for an efficient anti-cancer therapeutics. As these polymer based NPs has high mobility in the smallest capillaries, allowing for efficient uptake and selective drug accumulation at the target sites for a competent cancer therapy.

Keywords :

Nanoparticles, polymer, drug delivery, cancer therapy, polylactides, polyglycolides.

Article Info :

Received 07-Nov-2013, Revised 03-Apr-2014, Accepted 01-Dec-2013

 

 

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